Uncompetitive Inhibition

In uncompetitive inhibition, an inhibitor binds at a site distinct from the substrate.

Mechanism:

However, an uncompetitive inhibitor will bind only to the ES complex. On the other hand noncompetitive inhibitor binds to either free enzyme or the ES complex.

V_max and K_m, in uncompetitive inhibition:

In uncompetitive inhibition, apparent V_max and K_m both decrease.

Michaelis-Menten equation of uncompetitive inhibition:

The double-reciprocal form of the above equation:

Lineweaver-Burk plot: Uninhibited enzyme activity vs Uncompetitive inhibition:

Other related notes:

1. Competitive inhibition: https://thebiologyislove.com/competitive-inhibition-graph/
2. Noncompetitive inhibition: https://thebiologyislove.com/noncompetitive-inhibition/

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