Mixed Noncompetitive Inhibition

In mixed noncompetitive inhibition, the binding of the inhibitor with the enzyme influences the binding of substrate with enzyme.

Mechanism:

Either the binding sites for inhibitor and substrate are near one another or conformational changes in enzyme caused by the inhibitor affect substrate binding. In this case, K_I and K_I’ are not equal and both K_m and V_max are altered by the presence of the inhibitor.

Lineweaver-Burk plot of mixed noncompetitive inhibition:

a. K_I < K_I’

a. K_I > K_I’

Other related notes:

1. Competitive inhibition: https://thebiologyislove.com/competitive-inhibition-graph/
2. Noncompetitive inhibition: https://thebiologyislove.com/noncompetitive-inhibition/

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