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Helix Loop Helix motif

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The Helix Loop Helix motif (HLH) is involved in both DNA binding and protein dimerization.

The structure of Helix Loop Helix motif:

The HLH motif is composed of two regions of α helix of 15-16 residues separated by a region of variable length, which forms a loop between the two α helices.

The length of connecting loop varies from 12-28 amino acid residues. this motif is quite similar to the leucine zipper motif.

The diagrammatic representation of HLH motif:

Active HLH homodimer– participate in both DNA binding and protein dimerization.

Other DNA binding motifs:

  1. Introduction to DNA binding motifs: https://thebiologyislove.com/dna-binding-motifs/
  2. helix-turn-helix: https://thebiologyislove.com/helix-turn-helix-motif/
  3. leucine zipper motif: https://thebiologyislove.com/leucine-zipper-motif/
  4. zinc finger motif: https://thebiologyislove.com/zinc-finger-motif-c2-h2/

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